Publications

July 16, 2024

We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting.

March 28, 2024

Phase 1 trial shows autologous CD5.CAR T cells are safe and effective in r/r T-cell lymphoma with a 44% overall response rate, promising advances in T-cell malignancy treatment.

June 2, 2023

We describe improved responses in T-ALL patients during a Phase I dose study (NCT03081910) of autologous CD5-directed chimeric antigen receptor T cell (CD5 CAR T) following the addition of tyrosine kinase inhibitors during manufacturing.

News

January 28, 2025

March Biosciences Receives FDA Orphan Drug Designation for MB-105, a First-in-Class CD5 CAR-T Cell Therapy, for T-Cell Lymphoma

March Biosciences today announced that the FDA granted orphan drug designation to MB-105 ffor the treatment of relapsed / refractory CD5-positive T-cell lymphoma.

October 23, 2024

March Biosciences Closes Oversubscribed $28.4 Million Series A Financing

Mission BioCapital and 4BIO Capital led the financing with significant participation from new and existing investors to support Phase 2 development, raising over $51 million to date.

February 22, 2024

Cell therapy developed by Baylor scientists shows promise as woman remains cancer-free after 5 years

A CAR T cell therapy for T cell lymphoma showed promise in a Phase I clinical trial, Baylor College of Medicine scientists said.
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