Publications
July 16, 2024
We demonstrate that the expression of a chimeric antigen receptor (CAR) targeting CD5, a prominent pan-T cell antigen, induces rapid internalization and complete loss of the CD5 protein on T cells, protecting them from self-targeting.
March 28, 2024
Phase 1 trial shows autologous CD5.CAR T cells are safe and effective in r/r T-cell lymphoma with a 44% overall response rate, promising advances in T-cell malignancy treatment.
June 2, 2023
We describe improved responses in T-ALL patients during a Phase I dose study (NCT03081910) of autologous CD5-directed chimeric antigen receptor T cell (CD5 CAR T) following the addition of tyrosine kinase inhibitors during manufacturing.
News
October 23, 2024
March Biosciences Closes Oversubscribed $28.4 Million Series A Financing
Mission BioCapital and 4BIO Capital led the financing with significant participation from new and existing investors to support Phase 2 development, raising over $51 million to date.
February 22, 2024
Cell therapy developed by Baylor scientists shows promise as woman remains cancer-free after 5 years
A CAR T cell therapy for T cell lymphoma showed promise in a Phase I clinical trial, Baylor College of Medicine scientists said.
November 17, 2023
March Biosciences Awarded $13.4 Million by CPRIT to Advance Its CD5 CAR-T Therapy for T-cell Lymphoma in Phase 2 Trials
March Biosciences received a $13.4 million grant award from CPRIT to support continued clinical development of MB-105 CD5 CAR-T for T-cell lymphoma